No. A tire filled with nitrogen has the same rolling resistance and other characteristics that a tire filled with an equal amount of ordinary air has. The nitrogen you pump into your tires isn't 100 percent percent pure but typically around 93 percent to 95 percent nitrogen. The oxygen you breathe and pump into your tires is 78 percent nitrogen, so the difference isn't huge.
However, the benefit of nitrogen is that it doesn't leak out of tires as quickly as ordinary air, so in theory you could see some fuel economy benefit from using nitrogen. That assumes that if you use air, you wouldn't check your tire pressures on a regular basis and would routinely drive with underinflated tires, which reduce gas mileage. Fuel economy drops 0.3 percent for every pound drop in air pressure in all four tires, the U.S. Environmental Protection Agency says.
If you do pay attention to your tires and keep them properly inflated with air, you won't spend more money on gas or to buy nitrogen, which can run $3 or more per tire. Air is cheaper, even free.
*Excerpt from the Chicago Tribune